|Professor & Feinstone Chairman of Molecular Biology
Ph.D. U. Cincinnati College of Medicine
|University of Memphis
Department of Biology
Office: 511 Life Sciences Building
Memphis, TN USA 38152
Thomas Robert Sutter obtained his BS (1980) from St. Bonaventure University, NY, and
Ph.D. (1988) from the University of Cincinnati College of Medicine. His dissertation
research focused on the isolation and characterization of the yeast cytochrome P450
14a-demethylase and its reductase, essential enzymes for the synthesis of membrane
sterols, a pathway that is a primary target for antifungal agents. He completed postdoctoral
training at CIIT, Research Triangle Park, NC and then joined the faculty of the Johns
Hopkins University in 1991 where he was an Assistant and Associate Professor in the
School of Public Health. He joined the faculty of the University of Memphis in 1999
and is holder of the W. Harry Feinstone Chair of Excellence in Functional Genomics.
Research in this laboratory is focused on understanding the causation and prevention
of cancer. Topics include receptor-mediated carcinogenesis, the metabolism of hormones,
dietary and xenobiotic compounds, chemoprevention of cancer and genetic susceptibility.
Our approach to these topics has utilized gene expression assays to identify components
of the cancer process. The mechanistic role of these genes is determined using a multifaceted
approach that entails cloning of potential genes of interest, expression of recombinant
protein for enzymatic characterization, overexpression in cell lines appropriate for
the assessment of function, and if fully justified, the development of transgenic
animal models for the gene of interest.